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On your Linux computer, go to Dash > Applications > Internet > Synology Cloud Station Backup to launch the wizard. Click Next to continue. Do the following to configure the Synology product you want to back up to, and then click Next : Enter the name of your computer, the IP address, the QuickConnect ID, username and password of your …
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Aug 23, 2022· The US Preventive Services Task Force (USPSTF) concludes with moderate certainty that statin use for the prevention of CVD events and all-cause mortality in adults aged 40 to 75 years with no history of CVD and who have 1 or more CVD risk factors (ie, dyslipidemia, diabetes, hypertension, or smoking) and an estimated 10-year CVD event …
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May 11, 2022· Severe headache is one of the hallmark symptoms of hemorrhagic stroke. This is a very serious medical condition and requires immediate medical attention. 3. Fatigue. Some people taking statins may experience fatigue, especially when they exercise or move. Fatigue affects about 1% to 4% of people taking statins.
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Statins have antiatherosclerotic effects, that positively correlate with the percent decrease in LDL cholesterol. In addition, they can exert antiatherosclerotic effects independently of their hypolipidemic action. Because the mevalonate metabolism generates a series of isoprenoids vital for different cellular functions, from cholesterol synthesis to the control of cell growth …
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Purpose of review: In randomized trials and many observational studies, statins are associated with a modest excess of type 2 diabetes mellitus. High-intensity statins, such as atorvastatin 80 mg and rosuvastatin 20 mg, are associated with a higher excess risk of diabetes than moderate-intensity statins, such as atorvastatin 10 mg, simvastatin 20-40 …
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Nov 23, 2015· Statins inhibit HMG-CoA, which is a rate limiting step in cholesterol biosynthesis. 2 Statin therapy has been shown to be effective in lowering low density lipoprotein cholesterol (LDL-C) levels 20-50%, as well as lowering triglyceride levels 10-20% and causing a possible rise in serum high density lipoprotein cholesterol (HDL-C) …
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Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. By Mayo Clinic Staff Doctors often prescribe statins for people with high cholesterol to lower their total cholesterol and …
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Jan 21, 2021· Statins may be the most studied medicine in medical history, with more than 40 trials where statins were compared to placebo and shown to lower the risk of heart attack, stroke, and death in a high-risk group. Among medical experts, there is little debate these days on whether statins work in high-risk patients. The debate more commonly is …
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However, the excessive or long-term use of statins can cause in vitro cytotoxicity, in vivo liver injury, liver necrosis, kidney damage, and myopathy in both human beings and animals. Many studies indicate that oxidative stress is involved in the various toxicities associated with statins, and various antioxidants have been evaluated to ...
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May 05, 2018· Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By doing so, they have a potent lipid-lowering effect that reduces cardiovascular risk and decreases mortality. Since the mevalonate pathway also influences endothelial ...
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May 01, 2007· Abstract. The beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the modulation of lipid metabolism, derived from their effect of inhibition upon HMG‐CoA reductase. Statins have antiatherosclerotic effects, that positively ...
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Dec 22, 2020· Well, cholesterol is a fat-like, waxy substance that helps your body make cell membranes, many hormones and vitamin D. So, it's a very important component of the body's metabolism. And the cholesterol in your blood comes from two sources: the foods you eat and your liver. Your liver actually makes all the cholesterol your body needs.
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Sep 27, 2022· The most common side effects reported with statins include: a headache. belching or excessive gas. constipation. heartburn, indigestion, nausea or stomach discomfort. hoarseness. lower back or side pain. muscle pain, tenderness, or weakness. pain or tenderness around the eyes and cheekbones.
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Jul 22, 2021· Lipid-altering agents encompass several classes of drugs that include hydroxymethylglutaryl (HMG) CoA reductase inhibitors or statins, fibric acid derivatives, bile acid sequestrants, cholesterol absorption inhibitors, and nicotinic acid. These drugs differ with respect to mechanism of action and to the degree and type of lipid lowering.
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Aug 29, 2022· The "Medication, Discharge" datatype refers to the discharge medication list and is intended to express medications ordered for post-discharge use. This eCQM is an episode-based measure. This version of the eCQM uses QDM version 5.5. Please refer to the eCQI resource center for more information on the QDM.
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Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease.They are the most common cholesterol-lowering drugs. Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and …
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However, the rate of true statin-induced hepatotoxicity is exceedingly low. Moreover, multiple retrospective studies have shown that statins are not only safe for use in patients with cirrhosis, but are also likely beneficial in reducing liver decompensation, hepatocellular carcinoma, infections, and death. What confounds the concern related to ...
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